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Homocysteine thiolactone can cause damage to some types of cells, particularly the endothelial cells that line blood vessels

At the level of thyroid hormone synthesis, TNF- can directly inhibit the activity of thyroid peroxidase (TPO), and IL-1 stimulates iodothyronine 5-deiodine activity in the liver to affect the metabolism of thyroid hormone (Fujii et al., 1989)