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& Maack, C

Sometimes, other forms of hormone replacement therapy (HRT) may be necessary to achieve this balance

In Phase 3 clinical research, this combination has been examined for coordinated effects on appetite regulation, glucose metabolism, and metabolic balance

FIGURE 2 In addition to IGF-1R, insulin-like growth factor binding proteins (IGFBPs) are also required for IGF-1 bioavailability because they interact with IGF-1 with the same affinity as IGF-1R (Perks, 2023)