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Lmx1b is crucial for the development and differentiation of midbrain dopaminergic neurons, and it is also essential for the differentiation and survival of central serotonin neurons during embryonic development [3, 4, 629, 630]

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A recent Delphi consensus exercise redefined morphology and distribution terminology for TEN and reinforced the need for developing a skin-directed and morphologically based SJS/TEN scoring system [105]

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95 Future studies need to combine single-cell transcriptomics and ubiquitin-modified omics to analyze the dynamic regulatory network of the proteasome, UPS and ALP during aging to ensure the correct synthesis, folding, and degradation of proteins, effectively ameliorating age-related pathologies