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It also exerts direct effects on cellular function through its interactions with androgen receptors

A preclinical pilot study in human patients with chronic pain episodes found, that DSIP significantly reduced pain perception, also improved mood by reduction of depressive states, and that it may potentially be of interest for research into physiological addiction on pain medications, as it was observed to reduce withdrawal symptoms that occurs after discontinuation of long-term analgesic treatment

Doubling up is not supported by any published research and is not recommended

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As the ghrelin receptor also regulates growth hormone release, it can boost muscle growth (8, 9)