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Notably, Ca 2+ -mediated neurotoxicity appears to be source specific as Ca 2+ influx through L-type voltage-sensitive Ca 2+ channels is not as neurotoxic as Ca 2+ influx through NMDA receptors and AMPA receptors, suggesting the possibility of yet to be known ion-receptor interactions [128,132,137]

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Second, safety and ethical concerns persist, particularly for injectable systems such as PEGylated uricase, where immunogenicity and long-term tissue accumulation necessitate rigorous riskbenefit analyses

World Conference on Lung Cancer, 2016

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