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Managing GI side effects during the transition Gastrointestinal side effects are the number one reason people abandon GLP-1 receptor agonist therapy

While this is less than what GLP-1 medications achieve over longer treatment courses, phentermine offers distinct advantages: it's an oral medication (no injections), it's widely available as a generic, and it's covered by many insurance plans

Safe : Minimal side effects and approved for long-term use

Methods In this multicenter, retrospective, propensity score-matched cohort study using the TriNetX US Collaborative Network, we compared outcomes in 43,743 new tirzepatide initiators versus 43,743 matched SGLT2i users with MASLD and 1 metabolic comorbidity

The dosage charts gradual increase is designed to help minimize these, but if you experience nausea, digestive discomfort, or other issues, there are ways to manage them: Eat smaller, frequent meals Large meals can sometimes intensify nausea