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Endothelial dysfunction impairs renal microcirculation, reducing glomerular filtration rate (GFR) and promoting renal ischemia, accelerating progression to end-stage renal disease (120)

Topical treatment Palmitoyl tetrapeptide-20 and melitane are biomimetic peptides that act as agonists of -melanocyte-stimulating hormone (-MSH) and, together with its melanocortin-1 receptor (MC1R), regulate pigment production in hair