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Tirzepatide activation of both GIPR and GLP1R differs from current GLP1RA, such as semaglutide, liraglutide, dulaglutide and others, which only activate GLP1R (Fig

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However, the absence of a direct drug-drug interaction does not mean these medications can be combined without consideration

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It leverages large-scale databases such as TCMSP, STITCH, STRING, GeneCards, and OMIM to construct compound target pathway networks, helping researchers identify hub genes, key targets, and synergistic interactions