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B-complex vitamins, particularly riboflavin (vitamin B2), commonly cause bright yellow urine Medications and supplements : Numerous medications affect urine pigmentation, including certain antibiotics, laxatives containing senna, and chemotherapy agents Medical conditions : Liver disorders may cause dark urine due to bilirubin excretion, whilst urinary tract infections can cause cloudy or unusually coloured urine Exercise and metabolism : Intense physical activity can temporarily concentrate urine through fluid loss via perspiration For patients taking Mounjaro, gastrointestinal side effects represent the most relevant mechanism for urine colour changes