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2012 Sep;153(9):4580-7 108.9 Schmeltz LR, Blevins TC, Aronoff SL, Ozer K, Leffert JD, Goldberg MA, Horowitz BS, Bertenshaw RH, Troya P, Cohen AE, Lanier RK, Wright C 4th

Folkman, J

Overexpression of MDM2 results in decreased level and activity of p53 (Kubbutat et al, 1997) and provides an alternative to a p53 mutation in the sense that it inactivates p53