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Belujon and Grace, 2017)

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In male Wistar rats experiencing transient ischemic stroke, UA suppresses the upregulation of cerebrocortical Vegfa expression in the acute phase of stroke and reduces the MMP-9/TIMP-1 ratio in the brain cortex, indicating that UA treatment may aid in the downregulation of the VEGF-A/MMP-9 pathway to improve BBB integrity [54]

1 The second is a decline in egg quality, driven largely by reduced mitochondrial efficiency inside the egg cell and a gradual build-up of oxidative damage

doi:10.5664/jcsm.7640 Iftikhar IH, Valentine CW, Bittencourt LR, et al