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The mechanism accounting for this effect is unknown but a leading hypothesis is that an increase of sodium chloride in the macula densa due to SGLT2 inhibition triggers a cascade that reduces GFR through constriction of the afferent glomerular arterioles (tubuloglomerular feedback) (139,195)

Choose something as easy as walking around your block or just stretching in your living room, she adds

Zhang Z, et al