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Semaglutide is a single (GLP-1) agonist and tirzepatide is a dual (GIP + GLP-1) agonist, while Retatrutide is a triple agonist adding the glucagon receptor

Hermansen K, Bkdal TA, Dring M, Pietraszek A, Mortensen LS, Jrgensen H, Flint A: Liraglutide suppresses postprandial triglyceride and apolipoprotein B48 elevations after a fat-rich meal in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, cross-over trial

One caveat the literature is honest about: as of May 2026, no randomized controlled trial has yet tested resistance training as a counter-measure specifically to GLP-1-induced lean-mass loss

This incredible demand is driven by the millions of adults who struggle with their weight, showing just how big of an impact these treatments are having