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As Tirzepatide affects gastric emptying , its vital for those with certain contraindications to avoid use without professional medical advice

In animal and cell studies it is associated with upregulation of repair-related growth-factor and angiogenic signalling (for example VEGF-linked pathways), collagen and extracellular-matrix (ECM) remodelling, and modulation of inflammation, which underlies research interest in connective-tissue and gut-lining recovery

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For patients with established osteoporosis, vitamin D adequacy is essential for optimal response to bisphosphonates and other bone-active medications

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