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Although these treatments have been shown to be effective, very little thought is put into the mechanisms by which these so-called neurotransmitter imbalances occur

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Treatments with a family of lipid-lowering drugs known as fibrates (e.g., fenofibrate, bezofibrate) have been associated with an increased excretion of betaine in the urine and a rise in homocysteine concentration in the blood of patients with diabetes mellitus or metabolic syndrome (125, 126)

A cut-off of 2 in the backbone was applied for delimiting the solutions belonging to the same cluster

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