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doi: 10.1038/s41417-023-00696-x 107 MandulaJKChangSMohamedEJimenezRSierra-MondragonRAChangDCet al

Post-treatment, the expression of the serotonin reuptake transporter (SERT) significantly increased, while tryptophan hydroxylase-1 (TPH-1) expression significantly decreased in colonic tissue, suggesting exendin-4 mitigates visceral hypersensitivity by upregulating SERT and downregulating TPH-1