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Furthermore, a major drawback of GLP-1 agonist drugs is a high incidence of gastrointestinal problems, like nausea, vomiting, diarrhoea, and constipation

2022 DOI: 10.1016/j.cmet.2022.07.013 PMID: 35985340 Read on PubMed The Lancet LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist in people with type 2 diabetes: a phase 1b, multicentre, double-blind, placebo-controlled, randomised, multiple-ascending dose trial Urva S, Coskun T, Loh MT, et al

Last year, the World Health Organization (WHO) issued its first guideline endorsing GLP-1 therapies for the long-term treatment of obesity, recognizing it as a chronic disease and recommending these agents as part of comprehensive management strategies that include diet, physical activity, and structured care

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