Raf-1(Phospho Tyr341) Polyclonal Antibody, 20ul Inoculating Loops/Needles Heterozygous loss-of-function mutations in KLF1

Heterozygous loss-of-function mutations in KLF1 result in the dominant In (Lu) blood phenotype

RUFY1 (RUN and FYVE domain containing 1) encodes a protein that contains a RUN domain and a FYVE-type zinc finger domain

This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain| yielding disulfide-linked heavy and light chains

which suggests an essential role of this gene in the immune response to antigenic stimuli

The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription

Raf-1(Phospho Tyr341) Polyclonal Antibody, 20ul Inoculating Loops/Needles Heterozygous loss-of-function mutations in KLF1This gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.