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Endocrinology 143, 34543463

While taste changes during treatment with GLP-1 receptor agonists or dual GIP/GLP-1 receptor agonists are generally benign and self-limiting, certain situations warrant medical evaluation to rule out complications or alternative diagnoses

doi: 10.1016/S2213-8587(19)30068-3

For example, patients who administer 2.4 mg of semaglutide per week for chronic weight management experience more weight loss than those who receive a 1 mg dose of semaglutide

Bipolar disorder is also commonly accompanied by circadian and sleep disturbances, which could be linked to increased KP activity, as TRP is shunted away from 5-HT synthesis reducing melatonin production and potentially disrupting sleep-wake regulation [233]