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Drugs are not metabolized by the liver, but multidrug and toxin extrusion protein 1 (MATE1) expressed in hepatocytes is involved in the clearance of drugs, which is transported to the kidney through bile or through blood ( Figure 1 It is well known that the pharmacodynamic property of metformin is anti-diabetic, but there is growing evidence that it has a number of extra-hypoglycemic effects

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Your body can also produce it, provided you have sufficient protein and certain micronutrients supplied by a varied diet