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Why weight regain is so common Data show that most people who start GLP-1s for weight loss eventually quit taking them

Oxyntomodulin is a biased agonist relative to GLP-1 4 , and forms distinct and more dynamic interactions with the GLP-1R, particularly with residues at the base of the peptide binding cavity that is located above the conserved central polar network that is important for receptor activation

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doi: 10.1146/annurev-micro-091014-104422 16 HanaiT.ShirakiM.ImaiK.SuetuguA.TakaiK.ShimizuM