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That effect is what reduces appetite and creates the calorie deficit that drives weight loss

Eli Lilly and Company announced positive results from its Phase III trial study TRIUMPH-4 showing that retatrutide produced substantial weight loss and showed reductions in knee pain for adults with obesity or overweight and knee osteoarthritis

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At week 104, 52.4% of patients treated with semaglutide improved in their BMI category compared to 15.7% of those receiving placebo

The mechanisms of protein-triggered GLP-1 secretion are less clear, but the amino acid proportion and composition appear important to the stimulatory effect