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While Zepbound has helped many people reach their health goals, its important to understand what to watch for along the way

Weight-loss drugs can harm a developing baby, and it is not known if tirzepatide passes into breast milk

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In clinical trials for type 2 diabetes, fatigue was not identified as a frequent side effect occurring in more than 5% of participants

At the end of 40 or 42 weeks (study time varied by trial), urine albumin-to-creatinine ratio (UACR) was significantly reduced among participants assigned to tirzepatide 5, 10, or 15 mg as compared with those assigned to all pooled comparators (placebo, semaglutide, insulin degludec, and insulin glargine) with adjusted mean percent changes of 19.3% [95% CI 12.525.5%], 22.0% [95% CI 15.328.1%], and 26.3% [95% CI 20.032.0%], respectively, with a greater reduction observed in participants with a UACR 30 mg/g at baseline [96]