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Fresh preparation is essential, especially for topical applications where degradation products could irritate sensitized skin

Dysfunction of the PINK1-Parkin pathway in PD can lead to mitochondrial issues by obstructing mitophagy and disrupting ATP metabolism

It is generally agreed that we have no evidence that febuxostat is a negative for the heart, just the question of the CARES trial as to whether it is not as protective as allopurinol