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These medications work best as part of a comprehensive approach that includes dietary changes, physical activity, and lifestyle modifications

Reason for caution: GLP-1 medications may alter pancreatic enzyme secretion and ductal flow, potentially triggering or worsening inflammation in vulnerable individuals

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The key distinction: semaglutide itself clears relatively fast, but your body's response to the medicationincluding appetite regulation, glucose metabolism, and hormonal adjustmentsmay take longer to fully normalize

Instead, it is used as a part of a more comprehensive hormone replacement therapy plan