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The pharmacokinetic rationale is questionable given the 5-day half-life, but some users report better side effect tolerance with split dosing

Changing the dosing schedule on your own can disrupt this balance and may reduce effectiveness or even increase side effects

doi: 10.1016/S2213-8587(21)00203-5 10 DaviesMJBergenstalRBodeBKushnerRFLewinASkjthTVet al

To date, there have been 1,143 reports of acute and chronic pancreatitis to the yellow card scheme among patients taking semaglutide or tirzepatide, with 17 reported fatalities

Store tirzepatide in its original packaging on a shelf away from direct contact with cooling elements