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Both Highlights Semaglutide and tirzepatide are both GLP-1 receptor agonists, but tirzepatide has a dual mechanism of action because it also stimulates GIP production

A true allergy produces systemic symptoms (widespread hives, facial swelling, breathing difficulty)

If similar effects occur in humans, adding niacinamide to a tirzepatide regimen could theoretically amplify fat loss and improve metabolic flexibility