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The alanine at position 8, the residue immediately adjacent to the DPP-4 cleavage bond, is replaced by alpha-aminoisobutyric acid (Aib), a non-canonical, doubly methylated amino acid whose steric bulk blocks protease access [1]

Activation of c-Jun-N-terminal kinase in a rat model of intracerebral hemorrhage: the role of iron

Erceg et al., 2010)

when drugs display this biphasic elimination pattern, the half-life corresponding to the second phase is what is clinically relevant, and this half-life is known as the terminal half-life

Potential Side Effects and Considerations Retatrutide may cause side effects, especially as the dosage increases