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Broccoli and Brussels Sprouts : Cruciferous vegetables are excellent sources of cysteine, contributing to natural glutathione synthesis

Single KOs were maintained through heterozygous breeding, while double KOs were bred homozygously and WT mice were age-matched controls

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unlike SSRIs tested alongside it, PE22-28 appeared to reduce depressive markers without associated adverse effects in the model Seizure resistance rather than exacerbating seizure susceptibility (a theoretical concern with TREK-1 inhibition), pre-clinical data showed PE22-28 enhanced resistance to generalised seizures Cognitive function improvements in spatial memory and short-term recall have been observed in neurogenesis-associated cognitive models Anxiety models studied in corticosterone-induced models of stress and anxiety, PE22-28 demonstrated anxiolytic-consistent results in sub-chronic treatment protocols Cardiac safety TREK-1 inhibition typically raises concerns around QT prolongation

US Food and Drug Administration, Center for Drug Evaluation and Research