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These mechanisms may accelerate the pharmacokinetic changes in the affected drug and lead to clinically relevant DDIs, particularly in drugs with a narrow therapeutic window

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They concluded that significant weight regain began eight weeks after stopping AOMs and continued through 20 weeks, particularly for individuals who had previously taken glucagon-like peptide-1 (GLP-1) receptor agonists or those who had experienced greater weight loss during treatment or ongoing lifestyle interventions

10.1152/physrev.00050.2003 17 EvansD