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A phase I/II clinical trial found that the most common side effects were mild and transient (Teichman et al., 2006): Injection site reactions (redness, mild swelling) Headaches Flushing or warmth Temporary water retention Joint tightness or tingling Transient fatigue or dizziness Serious adverse events are rare when the peptide is used under medical supervision at appropriate doses

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[DOI] [PubMed] [Google Scholar] Malcon C, Kaddurah-Daouk R, Beal MF

Petersen, E.A., et al., High-frequency 10-kHz spinal cord stimulation provides long-term (24-month) improvements in diabetes-related pain and quality of life for patients with painful diabetic neuropathy