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"MOTS-c can significantly enhance physical performance in young, middle-age, and old mice." Reynolds et al., Nature Communications , 2021 [3] The ceiling on all of this is the same ceiling every mitochondrial peptide hits: the outcome data is rodent data

A common loss-of-function variant at rs601338 (W143*), results in a non-secretor phenotype in homozygotes, meaning these individuals cannot secrete ABO antigens in their gut lumen and other secretions (126)

Several factors influence how quickly and effectively GHK-Cu works: Individual Factors Age and Baseline GHK-Cu Levels: Older individuals, who naturally have lower GHK-Cu levels, may experience more pronounced changes as the peptide helps rebuild from a deeper deficit

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