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Under conditions of oxidative stress, NRF2 associates with Keap1 and activates the expression of downstream target genes containing AREs, such as ferric heavy chain proteins (FTH1) and ferric light chain proteins (FTL), which encourages GSH synthesis and regenerates NADPH to compete with ROS production (36, 83)

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In the per protocol analysis, looking at those still enrolled at 12 months, health improvements and weight loss were even greater, at 16.6% body weight loss on average

Qi et al., 2021), however, to our knowledge this had not previously been shown in the cerebrovasculature

Canto C, Menzies KJ, Auwerx J