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Serotonin levels, pain threshold, and fibromyalgia symptoms in the general population

Glycine has many cardioprotective effects: - increased antioxidant defense through glutathione - reduction in inflammation and oxidative stress - lowering of blood pressure - lowering of blood sugar - lowering of homocysteine - reduction in platelet aggregation PMID: 23615880 Glycine has many cardioprotective effects: - increased antioxidant defense through glutathione - reduction in inflammation and oxidative stress - lowering of blood pressure - lowering of blood sugar - lowering of homocysteine - reduction in platelet aggregation PMID: 23615880 Glutathione is the master antioxidant that protects the body against oxidative stress and inflammation Low glutathione levels contribute to aging and age-related diseases (PMID: 21795440) Glutathione synthesis is rate-limited by glycine (PMID: 29559876)In human coronary arterial endothelial cells, glycine, cysteine, and histidine exhibit anti-inflammatory effects (PMID: 22236003) Vascular endothelial growth factor (VEGF) signaling requires glycine to promote the growth of new blood vessels or angiogenesis (PMID: 29116138)Glycine also helps to balance methionine levels, which in excess can raise homocysteine (PMID: 27064126) Elevated homocysteine is a major risk factor for cardiovascular disease (PMID: 25577237)The decrease in vascular function in cardiovascular disease tends to promote ischemia and hypoxia (lack of blood flow and oxygenation in tissues) Glycine is necessary for the formation of heme and hemoglobin and thus oxygenation of cells (PMID: 28495915)In older adults, glycine levels are inversely associated with metabolic syndrome and cardiometabolic traits (PMID: 30568717) Supplementing with glycine improves metabolic syndrome, including diabetes, obesity, hyperlipidemia, and hypertension (PMID: 35013990)Overall, getting adequate amounts of glycine may be important for improving markers of metabolic health and antioxidant defense Check out my thread about how much glycine you would optimally need: x.com/siimland/statu Glycine extends mouse lifespan by 5% Join the conversation

Liu S, Yang Y, Song YQ, Geng J, Chen QL

Yet, studies indicating that CGRP agonists possess specific anti-inflammatory properties, as well as vasodilatory properties [138], might suggest that inhibiting CGRP could be of potential negative consequence in COPD